Immunotherapy Treatment of Berger's Disease

In Berger’s Disease, the immune system can not work well. When the foreign infection virus, bacteria etc invade into body, their relevant antibodies can not defeat them effectively. As a result, the antigens encounter and bind to antibodies to form immune complexes in blood. The complexes will flow into kidneys in blood circulation and then deposit in mesangial area. These immune complexes attract inflammatory factors ceaselessly, which will cause inflammation in kidneys and impair the mesangial cells thus resulting in the proliferation and hyperplasia of the cells. Moreover, the inflammation can cause the mesangial cells to produce type 1 and type 3 collagen resulting in accumulation of extracellular matrix. As a result, the renal fibrosis is activated and glomeruli ossify gradually.

After the above analysis of the pathogenesis of Berger’s Disease, the treatment of the disease should include clearing up immune complexes, suppressing inflammation, correcting immune dysfunction and restoring mesangial cells.

Immunotherapy is not a signal therapy, but a comprehensive treatment system including the western medicine and traditional Chinese medicine.

In immunotherapy, the application of hormone and medicines for autoimmune diseases with low side effects can suppress the inflammation effectively so as to stop further damage to renal tissues.

However, it is not possible for the immune complexes to deposit in kidneys for too long. The application of the modern blood purification not only can clear up the immune complexes in blood, but also can remove other metabolic wastes like creatinine, nitrogen etc.

But the techniques can not eliminate the complexes in kidneys. For this part of immune complexes, Micro-Chinese Medicine Osmotherapy can degrade the immune complexes and make the dissolve in blood. Finally, they will be passed out into urine through circulation.

As for the impaired mesangial cells, Stem Cell Transplant is applied to restore them. Stem cells are undifferentiated cells without developing specialized functions. In right body condition, they can differentiate into new cells to replace the damaged mesangial cells to function.

After the above systemic treatment, the renal function of the patients with Berger’s Disease will have an enormous improvement and avoid developing into Renal Failure totally.