Will IgA Nephropathy Develop Renal Failure

Renal failure describes a medical condition in which kidneys fail to remove toxic products out from our blood. A series of systematic disorders frequently encounter in kidney disturbance, including anomaly in fluid levels, deranged acid levels, elevated level in blood pressure, bone disease or even cardiovascular disorders etc. Say to the worst, IgA Nephropathy has chance to develop into uremia after undergoing a period of renal failure.
In IgA Nephropathy, individual’s pace to renal failure presents various. Here are some statistics for your reference.
30%~40% of patients contributes to renal failure within 10 years.
1%~2% of patients develops uremia in each year.
In primary Glomerulonephritis, IgA Nephropathy accounts for 15%~30% of chronic renal failure.
Normally, IgA Nephropathy tends to Chronic Renal Failure, which is more difficult to control, compared with Acute Renal Failure. Some signals come into being, when it goes toward to renal failure, including discomforts, edema, anemia and high blood pressure etc.
Right treatment benefits to delay renal disease becoming renal failure. By far, IgA Nephropathy hardly has a good prognosis by intervention of conventional treatment, especially by hormone medications only. Such therapy makes you feel better through putting symptoms into invisibility, but your renal function still falls down gradually. As long as your renal functions are improved, IgA Nephropathy can be reversed from renal failure.
Meantime, lifestyle is always associated with the possibility of renal failure. Good life habits will help delaying the process of renal failure. Starting today, you must quit smoking and drinking; change your diet and manage a proper one for yourself; do some mild sports and activities and never make yourself too tired; prevent yourself from cold or any other infectious diseases; if you are not sure whether your lifestyle is ok or not, you might have a talk with your doctors.

Signs of FSGS Relapse

Cold and infection. They are the common signs for FSGS coming back. Many patients complain that even a mild cold or infectious ailment triggers the increase of proteins or blood in urine. As FSGS is associated with an immune disorder, any virus or bacterium easily get you involved in relapse.
Bubbles in urine. When your Proteinuria is restarting, continuous bubbles usually appear in your urine. Keep close monitor in your urine changes. If many bubbles last long time, it is extremely possible to tell your renal disease is on the back way.
Swelling. One of marked sign for recurrence is swelling in eyes. It usually appears clearly when you get up in the morning and then it is gone after a period of time. Besides, you may find edema in other parts, such as legs, ankles and hand etc.
Weight gain. Weight gain is along with generalized body swelling. If you find you become fat in a short time, please tell it to your doctor and he will provide relative suggestion.
Poor appetite. When FSGS is at the corner, some patients show bad response in appetite. They fail to take enough food and feel fatigue easily than before.
Relapse of FSGS varies in length, severity and symptoms. Above signs are general signs for your reference. If you are undergoing any of these signals or other discomforts, you need to talk with your doctors or you can communicate with our online doctors. Never just let signs go. You should remember, the sooner you find the signs, the less long-term damage will done to you.

Patient Case: IgA Nephropathy Stage

Here is a case of IgA Nephropathy Stage 3 (FSGS) who gets rid of hormones gradually and gets a better effects.


Bella, Female, 21-year-old, USA


Dropsy in eyes.
1. Bella appeared to have dropsy in eyes in June, 2007 and got examinations in local hospital. At that time, urine protein 3+, occult blood 2+, diagnosis as Chronic Nephritis. She was given anti-inflammation treatment, but there shows no response.
2. Bella transformed into another hospital in her country and tests showed urine protein 3+, occult blood 3+. Renal biopsy revealed Focal Segmental Glomerulosclerosis—stage 3. Given prednisone, GTW and cyclophosphamide for 16 months, she didn’t get better.
3. Bella was hospitalized in our hospital on 23th, April, 2010. At that time, tests showed serum albumin 33.7g/L, 24-hour uric albumen ration 1.36g, BUN and Scr are both within normal range.
4. She adopted Micro-Chinese Medicine Osmotherapy third times per day. Meantime, she took prednisone 40mg/d and cyclophosphamide 2g/d for one month.
5. Her 24-hour uric albumen ration became 0.58g when she left our hospital on 24th, May, 2010. Then she was suggested to stop cyclophosphamide and reduced the dosage of prednisone to 25mg.
6. She continued Micro-Chinese Medicine Osmotherapy at home for three months. When she got recheck in local hospital at 2th, September, 2010, she said the result as follows: Serum Albumin 33.6g/L, 24-hour uric albumen ration 0.04g. At that time, prednisone has reduced to o20mg.
Discussion
IgA Nephropathy refers to the deposits of IgA and C3 in mesangial area. The main composition of IgA in glomeruli is IgA1, which mainly comes from the effects of B cells from marrow and lymphatic system and Th2 cell, as well as dietary antigen. According to medical experts, the deposits of IgA connect with the imbalance between Th1 and Th2.
The ingredients of Micro-Chinese Medicine have ability in regulating immune system and correcting the imbalance between Th1 and Th2, which can decrease the accumulation of IgA in renal area.

FSGS Relapse Causes

FSGS is a disorder of immune system. Anyone who gets FSGS has a low immunity against external factors. Once external virus invades human body, failed immune system hardly strong enough to stop all virus, thus causing FSGS reoccurring.
Hormone medication only.
Hormone medication can eliminate symptoms, such as Proteinuria, in a short time, but hormone only fails to recover FSGS. For the reason that hormone can not affect the further cause of the disease—renal lesions. Besides, long-term hormone medication will bring side effects for patients, which may also trigger the relapse of FSGS. Meantime, the dosage of hormone medications should follow doctor’s advices, thus avoids the recurrence of FSGS induced by the regular intake of hormone.
Various inducements
Many inducements can keep FSGS recurrent, even a mild cold, fatigue, bleeding or any infections. All these triggers are around daily life, which may work as b
lasting fuse for the recurrence.
Unsuccessful treatment
FSGS results from renal injury. Proteins or blood in urine is attributed to the damage. Only the treatment focuses on the remedy of renal lesions can FSGS avoid or reduce of FSGS. Only the treatment which aims at eliminating Proteinuria or Hematuria can’t control the relapse of FSGS successfully.
Therefore, patients with FSGS should adopt right treatment and not just take hormone only, so that they can avoid or reduce its relapse. Meantime, they should improve their immunity against frequent recurrences. Besides, patients should pay attention to daily infection, cold, fatigue and so on.

Chinese herbal medicine for FSGS

Chinese herbal medicine may be a good choice for FSGS (focal segmental glomerulonepritis)

There are millions of glomeruli in your two kidneys, which serves as filters to filtrate human blood. Just like a coffee filter, it keeps useful materials and expels waste through urination. FSGS spreads scars on some glomeruli, which damages and kills some glomerular cells, thus leads to the disorder of filtration.


TCM, known as Herbal medicine, is used to repair the damaged glomerular cells in treating FSGS. Derived from natural plants or herbs, TCM has no adverse effects on patients. More important, it gives patients a remedy by repairing the filtration function of damaged glomerular cells instead of just eliminating proteinuria or hematuria outwardly. Consequently, it prevents FSGS from relapsing more effectively and more thoroughly.
Then what about the killed glomerular cells induced by FSGS? They are out of therapeutic range of TCM.

A better curative effect of combination of TCM depends on your timely adoption. How much your glomerular function can achieve greatly lies on how well your present glomerular state is.

How Get Rid of Side Effects for your Kids with FSGS

How to get rid of side effects for your kids with FSGS? Natural Treatment and life style changes may a good choices.

Natural Treatment


Traditional Chinese Medicine prevails all over the word as famous its non-toxic property. Medical experts of Chinese medicine collect a series of herbs or plants containing material which helps remedying FSGS with its special curative effects, such as degrading immune complex, resisting inflammation and dilating blood vessels etc. After herbs and plants are boiled together, the medicine soup is used as oral administration for patients to recover their renal damage induced by FSGS. The medicine soup tastes a little bitter. If your kids can’t bear such a taste, external application is suggested for you to consider. (our online service provide external application information without charge)

Lifestyle changes


Arrange a better diet for your kids. Provide less salty food for her or him, which can help reduce water retention, remedying swelling in legs, eyes or feet.
Take some moderate exercise, such as walking and jogging, which improves your kids’ immune function.
Cheer up your kids. Good emotions assist to get rid of fret from your kid. You are suggested to build your kids confidence of recovery. Positive thinking usually gathers good results.

What Causes FSGS (Focal Segmental Glomerulonephritis)

Primary causes of FSGS (Focal Segmental Glomerulonephritis)
Primary causes of FSGS means that doctors have not found its underlying causes. Usually, it presents as Nephrotic Syndrome. However, there are several currently genetic reasons which are associated with FSGS.
● ACTN4. It encodes alpha-actinin 4. This protein crosslinks bundles of actin filaments and is present in the podocyte. Mutations in this protein associated with FSGS result in increased affinity for actin binding, formation of intracellular aggregates, and decreased protein half-life.
● TRPC6. It encodes a member of the canonical family of TRP channels. This family of ion channels conducts cations in a largely non-selective manner.
● CD2AP or CMS. The protein expressed by this gene is expressed in podocytes where it interacts with fyn and synaptopodin.
● APOL1. According to Nephrologists, these variants arose as a defensive mechanism againstTrypanosoma brucei rhodesiense or some other sub-Saharan parasite despite conferring high susceptibility to FSGS when inherited from both parents.
● INF2. It encodes a member of the formin family of actin-regulating proteins. The observation that alterations in this podocyte-expressed formin cause FSGS emphasizes the importance of fine regulation of actin polymerization in podocyte function.
● NPHS2. Mutations in the NPHS2 gene, which codes for the protein called podocin, can cause focal segmental glomerulosclerosis.
Secondary cause of FSGS (Focal Segmental Glomerulonephritis)
Secondary cause of FSGS means that it is associated with the other disorders.
● Infections, including HIV, Hepatitis B and Parvovirus.
● Diseases, such as massive obesity, sickle cell nephropathy and congenital cyanotic heart disease.
● The damage to glomeruli. There are thousands of tiny filters in kidneys, called glomeruli, which overworks to push their limits by other diseases.
No matter primary or secondary FSGS causes, it is sure that FSGS results from the damage of glomerular basement membrane. What we can do is to repair the impaired glomeruli, thus avoids or delay the progress of FSGS (Focal Segmental Glomerulonephrits)

Immunotherapy for FSGS

No matter which stage of FSGS you are stepping in, it is sure that damaged and failed renal cells leads to the following disorders. As long as the failed and damaged cells are repaired or replaced by new ones, you will have the chance to reverse your poor condition, such as Proteinuria, Hematuria and backache etc. Cord Blood Immunotherapy always are regarded the saver. After transplanted into human body, immunotherapy can move to failed cells and perform similar renal function. In this way, you will get a healthier kidney. If you can also repair your damaged cells, you are surely welcomed to possess normal kidneys. The key is to find an effective immunotherapy.
Compared with other immunotherapy, cord blood immunotherapy shows more effective in treating FSGS. After childbirth, umbilical cord usually is throw away together with placenta. The collection of cord blood immunotherapy begins after the mother gives birth to a child. There is not any effects on mother or fetus. In other words, collection of cord blood immunotherapy turns “waste” into wealth.
Compared with other immunotherapy, cord blood immunotherapy have a high concentration and high quality, whose concentration rate is 15~20 times higher than that of bone marrow immunotherapy. Meantime, cord blood immunotherapy has a higher generative ability than others. As placenta has a good filter ability, so cord blood immunotherapy has a higher purity. For this reason, cord blood immunotherapy has a lower rate to get infection.
As an advanced medical technique, cord blood immunotherapy can absolutely provide you benefit. It may bring you a better effect and healthier life, which you have never expected. If you are tired of relapse of FSGS, unsatisfactory curative
effects from other therapies, you can mail to kidneyask@hotmail.com
Can you stop FSGS early?

Diet For Focal Segmental Glomerulonephritis (FSGS)

◆ FSGS is the Stage 3 of IgA Nephropathy. At the first two stages, high blood pressure rarely appears (lower than 5%~10%). With the disease developing, the morbidity of hypertension tends to become higher. When it progresses into FSGS, hypertension will become one common symptom of patients. At that time, patients might take some food which helps preventing the elevation of blood pressure. Such as, fresh green vegetables, sea-tangle, agaric, oat, black rice, black fungus, nori etc. Meantime, patients can drink green tea or yoghourt.
◆ Control the intake of energy; patients are advocated to complex carbohydrates, such as amylum starch, corn etc, so as to avoid the increase of blood fat.
◆ If you are suffering from severe edema or hypoproteinemia, you should take enough rest. Take high quality protein with the stand of 1g/KG/Day. You need enough heat (30~35 kilocalorie), but you are not advised to take high protein diet. (high quality protein≠high protein).
In edema, patients should take low-salt (3~6g/d) diet instead of salt-free diet. You can take less high saturated acid food (animal fat) and take more low saturated food (plant oil) or high soluble fiber (vegetables, oat and rice bran).
◆ As FSGS patients usually take long time of hormone medicines, they also can supplement some calcium medicine, such as calcium tablet.
The above information is for your reference. However, diet plans for FSGS (Focal Segmental Glomerulonephritis) vary from condition to condition.

Top 6 Ways for FSGS Patient to Improve Kidney Function

Improving FSGS Kidney Function Can Be Simple. Top 10 ways for FSGS patients include:
Top 1 The Water Hydration Technique
The actual fact matter is that every time you a drink a glass of water (or any fluid) in a hurry, you are placing pressure on kidney function. How? Well, seeing as one of the functions of the kidneys is to keep the fluid levels in the blood stream balanced, by drinking a full glass of water at once you are essentially dumping a large amount of water into the blood stream, which the kidneys now need to balance out (i.e. increase urine production).
Top 2 Exercise
The proper exercise for FSGS to improve kidney functions, include:
increases self-esteem, reduces the risk of diabetes, improves blood sugar, lowers blood pressure, reduces ‘bad’ cholesterol, increases ‘good’ cholesterol and assists weight loss.
Top 3 Water
Drinking a lot of water prevents dehydration and aids the kidneys in filtering the blood. The kidneys need water to produce urine. Without it, the waste forms solid kidney stones that are painful to pass through your urethra. Drinking water also prevents urinary tract infections.
Top 4 Vegetables
One of the ways to increase kidney health is to cut back on protein. You can replace large amounts of proteins in your diet with vegetables. Two or three times a week, try making vegetables the main component of your meal instead of meat.
Top 5 Stop smoking
We're all aware of what smoking does to the lungs and heart. Smoking also affects the tiny blood vessels in the kidney, damaging the internal structure and leading to kidney disease and failure.
Top 6 Asparagus
Let me just recap the main points of this marvellous healing vegetable:
- Helps maintain and assist kidney function
- Acts as a diuretic, therefore increases urine production
- Soothes the entire urinary system
- Helps eliminates excess fluid
If the kidney fails into Kidney Failure Stage, patients are suggested to see a doctor as soon as possible.

How to Deal with The Relapse of FSGS

Why does FSGS (Focal Segmental Glomerulonephritis) relapse?There are three conditions in which FSGS easily relapses.
● In terms of symptoms, FSGS is a latent kidney disease in some degree. Many patients can’t feel much discomforts before they are diagnose with FSGS. As a result, a number of patients have already stepped into the end stage of FSGS, which is difficult to be reversed for they have lost the best-time treatment. Consequently, the delay in treatment and poor renal condition usually call FSGS back.
● Not every patient is diagnosed with severe renal condition when they are found to have FSGS. Also, they adopt treatment timely for remedying their renal state. However, they still can find their FSGS coming back. Why? According a survey, in this condition, many renal disease patients fail to choose a proper treatment for themselves. Currently, some therapies only aim at reducing symptoms and delaying the complications, but they fail to stop their kidneys deteriorating and can’t focus on underlying causes. When they find their symptoms gone, they think troublesome FSGS left already. In fact, as long as underlying causes isn’t removed, they will experience the relapse shortly after.
● There are also a few luck patients who can find a successful treatment which aims at the rooting cases and receive an effective output after treatments. Why do some of them still suffer from recurrences? Generally speaking, they lose enough attention in daily care. Cold, chill, fatigue, insufficient rest, each of the inducement can trigger FSGS again.
How to treat FSGS (Focal Segmental Glomerulonephritis)?
● Take exam and test regularly. Once you are diagnosed with abnormal in renal condition, take a measure as soon as possible.
● Choose right therapy. The treatment on FSGS should not only reducing symptoms, but also repairing damaged renal tissue, as well as improving renal function.
● Keep good daily care. After treatment, patients should also take care of themselves in daily life. Take preventive measures to avoid the inducing agents, such as cold, bleeding, fatigue etc.
For any confusion of FSGS and its treatment, health care, mood management, dietary advices, you can leave a comment below.

Is FSGS Curable

I got a call from Canada asking about whether his FSGS can be cured or not. Here are my answers for anyone who is troubled with the same problem.
If you get FSGS from hereditary gene, in other words, your father or mother who suffer from it, there is no cure for you theoretically. Not with western medicine, Chinese medicine or other therapies. Even kidney transplant is not a cure, contrary to popular belief.
However, it doesn’t mean you can’t do anything for yourself. What you need is to choose a right therapy as soon as possible, in which way you can slow down its progress and even make it never relapse again.
If you are diagnosed without familial factors, whether you can be cured depends on your own condition.
If you are in the very early stage of FSGS, surely you have a great possibility in recovering from it. Most discomforts induced by FSGS can be stopped if caught early enough. And I have to remind you that it is the best time to adopt right treatment, so don’t just let it go for you haven’t feel too much discomforts. In most cases, FSGS just plays a role as “silent killer”—it is damaging your renal function, even though it shows no obvious symptoms. Our hospital received many cases who have stepped into the end stage of renal disease when they realized to see a doctor.
If you are entering the middle stage or even end stage of FSGS, it is basically impossible for you being cured. In such stages, your renal function has already reduced in a marked degree. Once your renal function is lost, it is hard to call it back.
However, if you choose the treatment which fix eyes in improving your renal function in place of just taking medicines or dialysis to eliminating your symptoms. You are surely to live a normal life in your rest life with FSGS uncured.
Whether your treatment aims at improving your renal function or not, you can get a guideline from our online service. And if you are wander whether your condition of FSGS or other kidney diseases can be cured or not, you can mail to kidneyask@hotmail.com

Focal Segmental Glomerulonephritis (FSGS) and Diet

Maintaining a proper diet is a very important step in fighting FSGS (Focal Segmental Glomerulonephritis). Managing a right diet plan contributes to controlling the progress and many symptoms.
◆ Control the intake of energy; patients are advocated to complex carbohydrates, such as amylum starch, corn etc, so as to avoid the increase of blood fat.
◆ FSGS is the Stage 3 of IgA Nephropathy. At the first two stages, high blood pressure rarely appears (lower than 5%~10%). With the disease developing, the morbidity of hypertension tends to become higher. When it progresses into FSGS, hypertension will become one common symptom of patients. At that time, patients might take some food which helps preventing the elevation of blood pressure. Such as, fresh green vegetables, sea-tangle, agaric, oat, black rice, black fungus, nori etc. Meantime, patients can drink green tea or yoghourt.
◆ As FSGS patients usually take long time of hormone medicines, they also can supplement some calcium medicine, such as calcium tablet.
◆ If you are suffering from severe edema or hypoproteinemia, you should take enough rest. Take high quality protein with the stand of 1g/KG/Day. You need enough heat (30~35 kilocalorie), but you are not advised to take high protein diet. (high quality protein≠high protein).
In edema, patients should take low-salt (3~6g/d) diet instead of salt-free diet. You can take less high saturated acid food (animal fat) and take more low saturated food (plant oil) or high soluble fiber (vegetables, oat and rice bran).

Update Treatment 2012 of FSGS

Latest research investigates from the causes of FSGS. FSGS is the third stage of IgA Nephropathy, which flows from persecution of immune complex deposits. With its accumulation in mesangial area, it will damage renal tissue, leads to insufficiencies of oxygen and blood, thus forms some scars (renal fibrosis) in glomeruli. As a result, a number of proteins flow into urine.
Latest research of FSGS points out that the right treatment on FSGS should remedy both the relative symptoms and underlying renal lesions, which follows the following properties.

◆ Right treatment should have functions in eliminating the accumulation of immune complex and removing the excess byproducts of metabolism, thus improves renal function in excreting toxins.
◆ The ideal treatment should block the renal fibrosis beyond all. In this way, it can prevent scars spreading continuously.
◆ It should fix to repair the damaged renal cells and make them go back to normal function. Only in this way, proteinuria can recover from the root.
◆ Dilating blood vessels should be another function of right treatment, which can provide enough oxygen and blood to renal lesions and enhance the blood circulation of kidneys.

It is believed that Traditional Chinese Medicine is closest to all standards. For their detailed properties, you can get instant reply from our online service or mail to us (kidneyask@hotmail.com )

Nephrotic Syndrome and FSGS

Identification of the gene or genes involved in primary idiopathic nephrotic syndrome could provide insight into the cause of the disease, as well as new treatment strategies.
Genes and Nephrotic Syndrome
Although the cause of primary nephrotic syndrome is not understood, it is generally thought to be due to an abnormality of the filtering units of the kidney called glomerulus. The incidence of primary nephrotic syndrome is variable and depends upon the ethnic background, which suggests a genetic tendency. The African-American population is especially susceptible to a particularly severe form of nephrotic syndrome called focal segmental glomerulosclerosis (FSGS). A particular type of nephrotic syndrome called congenital nephrotic syndrome of Finnish type (CNF) is especially common in the Finnish population and is a distinct entity.
FSGS
Focal Segmental Glomerulosclerosis (FSGS) is a rare disease that attacks the kidney’s filtering system (glomeruli) causing serious scarring. FSGS is one of the causes of a serious condition known as Nephrotic Syndrome.
Focal Segmental Glomerulosclerosis means:
Focal = some
Segmental = sections
Glomerulo = of kidney filters
Sclerosis = are scarred
Symptoms of Nephrotic Syndrome and FSGS
Common symptoms include edema, or swelling, especially in the legs, hypertension and high blood pressure, although in many cases, no clinical signs appear.
Complications
High protein levels in the urine can lead to high cholesterol and increased blood clotting. Complete renal failure, which requires a kidney transplant or dialysis, can occur when FSGS is left untreated.
Nephrotic Syndrome and FSGS facts
There are currently 19,306 people living with ESRD due to FSGS , in part because it is the most common cause of steroid resistant Nephrotic Syndrome in children, and it is the second leading cause of kidney failure in children. People of African ancestry are at a five times higher diagnosis rate of FSGS. About half of FSGS patients who do not respond to steroids go into ESRD each year, requiring dialysis or transplantation. Approximately 1,000 FSGS patients a year receive kidney transplants. However, within hours to weeks after a kidney transplant, FSGS returns in approximately 30-40% of patients.