Most patients with minimal change of IgA Nephropathy only presents Hematuria and has no obvious pathological change, therefore some of them just let it go and hope it can cure itself. In fact, timely treatment is very necessary, for minimal change can aggravate patient’s condition, even progress into eventual uremia with unsuccessful control
Minimal Change refers to that glomeruli are normal under the light microscopy and only a few parts appear to have slight broadening of mesangial area, with or without mesangial cells' proliferation. It is the level I, according to Lee’s Classification of IgA Nephropathy. The higher the level is, the severer the pathological change is.
By far, it is impossible for IgA Nephropathy disappears spontaneously without any treatment. However, if patient’s condition can be controlled at the early stage and keep it stable in a long time, patients usually can live a normal life. If not, patient’s condition will continue to aggravate and appear to have cresent, glomerulosclerosis and renal tubular fibrosis (similar with necrosis, you can refer to Grades of IgA Nephropathy) etc.
In clinic, without timely treatment, mild disease will come along with Hematuria accompanied with proteinuria, hypertension and edema etc from the simplex blood in urine. Once these obvious symptoms appear, patients always step into Level IV or Level V, which makes recovery and treatment more complex and hopeless.
According to clinical practice, if patients accept treatment to repair damaged renal tissue, stop renal persistent injury and block renal fibrosis, patients can keep their condition stable in a long time and show a good prognosis. Otherwise, patients will have to experience continuous relapse of IgA Nephropathy, which even can be triggered with mild cold or infection. Frequent recurrence
deteriorates renal fibrosis and eventually become renal failure and uremia.
