Immunotherapy And IgA Nephropathy

How can we treat IgA Nephropathy effectively?

Modern medical science has no an agreed treatment scheme for IgA Nephropathy and the comment on the effect is also different. Therefore, the discussion of the effective intervention measures of immunotherapy for preventing the aggravation of IgA Nephropathy and reducing the occurrence of Uremia has vital significance.

IgA Nephropathy can be completely cured by immunotherapy through restraining immune reaction, eliminating immune complex and regulating immune system. We can achieve this purpose by the following six steps:

Ⅰ. After patients arrive at our hospital, our experts will firstly make a comprehensive and systemic diagnosis of your illness condition, and then make a personalized treatment schedule for you.

Ⅱ. Through cooperating with foreign hospitals around the world, we introduce the newest immunosuppressive drugs with lowest side effects. Moreover, we create the immune blocking methods which can eliminate the abnormal inflammation and cease the intrinsic cell damages rapidly.

Ⅲ. Immune tolerance stage. At present, there is no effective medication which can clear up the immune complex, so we should make the body adaptive to the deposits of kidneys.

Ⅳ. Immune adjustment treatment. Western medicines can not eliminate the immune complex effectively, but we find useful methods in Chinese medicine. Through applying Chinese medicine, we can not only remove the immune complex but also improve the immunity of human body.

Ⅴ. Immune protection stage. During the treatment process, we can find ways to protect the damaged kidney tissues and inherent cell from being impaired again.

Ⅵ. Immune clearance treatment. According the patients’ characteristic, immunoadsorption, plasmapheresis and blood purification are used to help us eliminate the immune complex completely.

Herbal Treatment for IgA Nephritis

What's the meaning of herbal treatment?

Herbal treatment for IgA Nephritis (Berger's disease) means that treating IgA Nephritis with herbs. Herbal treatments refer to a type o alternative medicine that originates for plants and plant extracts. Used to heal illness and disease and to address psychological concerns, herbal treatments have been around for centuries, and were the precursor to modern medicine. Herbal remedies are obtained from a wide variety of natural resources including plant leaves, bark, berries, flowers, and roots. Herbal treatment has a history of more than two thousand years of history and remains a popular alternative throughout China. Moreover, it is growing in popularity all over the world.

How to treat IgA Nephritis (Berger's disease) with herbal remedy?

IgA Nephritis is featured by deposits of immune complex in the mesangial area of kidneys. The renal tissues and inherent cells are damaged. Over time, the kidney function can be impaired gradually by increasing immune complex deposition. At present, there is no effective western medical method which can remove them, but nephrologists in Shijiazhuang Kidney Disease Hospital find a solution in herbal medicine. Experiments show that some herbs are effective in treating IgA Nephritis. What's more, the therapy has been proved to be effective in dealing with kidney disease in clinical.

As we all know, the treatment effects of Chinese medicine are slower than western medications, so our nephrologists create an innovative therapy based on herbal medicines, called Micro-Chinese Medicine Osmotherapy. It comes into being through combining traditional herbal treatment with modern medical technology. Under the treatment, further damage can be stopped, the blood circulation and nutrition supply are improved, and the impaired renal tissues and inherent cells can be repaired, so the renal function is improved in a large degree. Besides, Micro-Chinese Medicine Osmotherapy is external applied, so while receiving this treatment, IgA Nephritis patients do not feel any pain or uncomfortable.

Immunotherapy: The Latest Treatment of IgA Nephropathy

In healthy condition, the immune system is a protecting system for our body and the immune cells can eliminate the foreign pathological substance. Hence, our body can keep in a normal and healthy state. However, in some cases, the immune system is initiated improperly. As a result, an antibody called immunoglobulin A (IgA) lodges in glomeruli and affecting their filtering ability gradually. Once the glomeruli are impaired, the patients will present a series of clinical symptoms like proteinuria, hematuria, and high blood pressure and so on. In order to treat IgA Nephropathy radically, it is the key to clearing up the deposited immunoglobulin A and regulating the immune system. The therapeutic mechanism of immunotherapy in the treatment of IgA Nephropathy is as follows:

1. In immunotherapy, blocking immune activation can prevent the immunoglobulin A from lodging in glomeruli further.

2. As the deposited immunoglobulin A is the underlying cause of glomerular inflammation, blood purification technique is applied to clear up the abnormal immunoglobulin A in blood.

3. In the immune regulation of immunotherapy, Micro-Chinese Medicine Osmotherapy can degrade the deposited the immune complexes and discharge them out of body when urinating. Meanwhile, Micro-Chinese Medicine Osmotherapy also can regulate the immune system and enhances the self-clearance ability of the body.

4. As the immune complexes immunoglobulin A has impaired renal cells, to improve the renal function, it is very important to restore the damaged cells. On one hand, Micro-Chinese Medicine Osmotherapy can dilate blood vessels and increase the oxgen, blood and micronutrients supply to kidneys thus enhancing the self-repairing of the diseased cells. On the other hand, the infusion of stem cells can replace the totally necrotic cells with new ones. Therefore, the renal function will improve enormously and even recover normal.

IgA Nephropathy: Symptoms and Prognosis

Symptoms of IgA Nephropathy

* Gross hematuria: It usually occurs a short time (24~72 hours) later after upper respiratory infection. Sometimes, the persons are also accompanied by mild systemic symptoms like muscle pain, painful urination, low fever ad back pain. The gross hematuria usually occurs frequently and it may convert to microscopic hematuria after a period.

* Microscopic hematuria with or without asymptomatic proteinuria: It is very common among children and adults.

* Proteinuria: It is usually mild and the urine protein is less than 1 gram in 24 hours. However, in a minority of cases, the persons may suffer from massive proteinuria and even Nephrotic Syndrome.

* Rapidly progressive nephritis syndrome: It is rare. The persons usually have persistent gross hematuria, massive of proteinuria. The renal function aggravates in a very short time along with edema and mild or moderate high blood pressure.

* Others: For the patients with typical clinical symptoms, they often experience intense pain in back and abdomen along with kidney stone. In this case, the disease is usually are misdiagnosed as kidney stone, pyelonephritis or acute gastroenteritis.

Prognosis of IgA Nephropathy

The following factors can influence the prognosis of IgA Nephropathy.

* The prognosis of IgA Nephropathy is poorer in male than female. What’s more, the earlier the disease starts, the worse its prognosis will be.

* For the persons with frequent gross hematuria, the prognosis is bad.

* If the persons with IgA Nephropathy develop massive proteinuria or Nephrotic Syndrome, the prognosis is not good.

* If the persons with IgA Nephropathy have a poor control of blood pressure, the prognosis is bad.

* If the pathological change in IgA Nephropathy such as crescent formation, interstitial fibrosis etc, the prognosis is bad.

Life Expectancy of Berger's Disease

If the patients can receive proper treatment as early as possible, the disease will not affect their patients’ life expectancy at all.


In early stage of Berger’s Disease, if the patients’ do not receive effective treatment, it is very likely to lead to a series of complications like high blood pressure, Nephrotic Syndrome and even massive proteinuria. In turn, these complications will certainly accelerate the disease progression. The conventional therapies like medications for high blood pressure, hormone etc can relieve the complications and symptoms of IgA Nephropathy temporarily. However, they only focus their symptoms, but can not treat the diseases from its underlying causes. Therefore, the conventional therapies can not extend the life expectancy of the patients with Berger’s Disease.


Immune dysfunction plays the major role in Berger’s Disease. In some cases, the immune system is activated improperly. When the foreign pathological substances invade into body, the relative antibodies are produced by immune system. However, for immune dysfunction, they can not tell the antigens and the healthy cells and tissues. As a result, a larger amount of antibodies complexes deposit in mesangial cells thus resulting in immune injury to mesangial cells. Once the mesangial cells are damaged, they can not function normally. Therefore, a lot of protein and red blood cells will leak into urine.

As for the treatment of Berger’s Disease, immunotherapy has showed its enormous therapeutic effect. It can suppress the inflammation of kidney, repair the damaged mesangial cells as well as rebuild immune system.

In immunotherapy, Micro-Chinese Medicine Osmotherapy can degrade the immune complexes and extracellular matrixes and make them dissolve in blood. Afterwards, these harmful substances will be excreted in urine. Therefore, it can stop the further damage to kidneys.


As the mesangial cells have been impaired by immune inflammation, to improve renal function, Stem Cell Transplant is intervened to restore them. Stem cells are undifferentiated cells with infinite differentiation and regeneration ability. After the stem cells are cultured, they will be infused into patients’ body through vein. The stem cells can differentiate into new cells to replace the necrotic cells to function.

After the kidneys are restored very well, their function will improve enormously and even recover normal. Therefore, the complications and symptoms relative to Berger’s Disease will disappear afterwards.

Immunotherapy Treatment of Berger's Disease

In Berger’s Disease, the immune system can not work well. When the foreign infection virus, bacteria etc invade into body, their relevant antibodies can not defeat them effectively. As a result, the antigens encounter and bind to antibodies to form immune complexes in blood. The complexes will flow into kidneys in blood circulation and then deposit in mesangial area. These immune complexes attract inflammatory factors ceaselessly, which will cause inflammation in kidneys and impair the mesangial cells thus resulting in the proliferation and hyperplasia of the cells. Moreover, the inflammation can cause the mesangial cells to produce type 1 and type 3 collagen resulting in accumulation of extracellular matrix. As a result, the renal fibrosis is activated and glomeruli ossify gradually.

After the above analysis of the pathogenesis of Berger’s Disease, the treatment of the disease should include clearing up immune complexes, suppressing inflammation, correcting immune dysfunction and restoring mesangial cells.

Immunotherapy is not a signal therapy, but a comprehensive treatment system including the western medicine and traditional Chinese medicine.

In immunotherapy, the application of hormone and medicines for autoimmune diseases with low side effects can suppress the inflammation effectively so as to stop further damage to renal tissues.

However, it is not possible for the immune complexes to deposit in kidneys for too long. The application of the modern blood purification not only can clear up the immune complexes in blood, but also can remove other metabolic wastes like creatinine, nitrogen etc.

But the techniques can not eliminate the complexes in kidneys. For this part of immune complexes, Micro-Chinese Medicine Osmotherapy can degrade the immune complexes and make the dissolve in blood. Finally, they will be passed out into urine through circulation.

As for the impaired mesangial cells, Stem Cell Transplant is applied to restore them. Stem cells are undifferentiated cells without developing specialized functions. In right body condition, they can differentiate into new cells to replace the damaged mesangial cells to function.

After the above systemic treatment, the renal function of the patients with Berger’s Disease will have an enormous improvement and avoid developing into Renal Failure totally.

IgA Nephropathy Relapse and Transplanted Kidney

Some researches show that the reoccurence rate of IgA Nephropathy to transplanted kidney varies from 50% to 80% cases. The disease can return even several years or even days. Why is the reoccurence rate so high? Is there alternative treatment to Kidney Transplant?

Causes of IgA Nephropathy reoccurence after Kidney Transplant

IgA Nephropathy is an autoimmune disorder, in which the patients' immune system attacks the healthy tissues and cells.

In normal case, when the foreign pathological stuffs(antigens) invade into body, the relative antibodies are activated by immune system to defeat them. The immune complexes of antigens and antibodies will be discharged out of body through systemic circulation.

However, when immune system is activated improperly, the immune complexes will build up in blood. As there are binding epitopes for the immune complexes, they will flow into kidneys and deposit there. The body mounts an inflammatory response to remove these foreign harmful substances, resulting in damage to glomeruli( filters) in kidneys. Afterwards, a series of symptoms occur such as proteinuria, hematuria etc.

In Kidney Transplant, although the diseased kidney is replaced by a healthy kidney, the patients' immune system is not regulated yet. Therefore, the patients' immune system may attack the transplanted kidney again, triggering the reoccurence of IgA Nephropathy.

Alternative treatment to Kidney Transplant for IgA Nephropathy

Immunotherapy is a new and alternative therapy for IgA Nephropathy other than kidney transplant.

Immunotherapy refers to a therapy that treats disease by suppressing, enhancing or inducing an immune response. It plays the following roles in treating IgA Nephropathy.

① Immunotherapy can remove the immune complexes in blood and kidneys. Hence, it can stop the immune injury to kidney tissues and cells immediately.

② It can regulate patients' immune system and stop excessive production of pathological antibodies. Therefore, it can prevent the formation of immune complexes.

③ It aims at eliminating the symptoms of IgA Nephropathy by restoring the impaired kidney tissues and cells..

Fish Oil and IgA Nephropathy

Fish oil is believed beneficial to alleviate IgA Nephropathy for its rich omega-3.

Omega-3

Omega-3 fish oil provides essential fatty acids that cannot be made by our bodies but must be supplied by our diet. These include linoleic and linolenic acids, which are found in black currant, borage, primrose and flax oils as well as fish, EPA (eicosapentaenoic acid), and DHA (docosahexanenoic acid).

Is Omega-3 really useful in IgA Nephropathy?

The strongest piece of evidence that fish oil is useful in the treatment of IgA Nephropathy comes from the Mayo Clinic-initiated study published in the NEJM in 1994 by Donadio et al. Briefly, this study looked at over 100 patients with IgA Nephropathy and persistent proteinuria, randomizing patients to receive either fish oil or an olive-oil placebo. Over a period of two years, only 6% of patients in the fish oil group displayed an increase of 50% or more in the serum creatinine, whereas 33% of those in the placebo-treated group suffered an increase of 50% or more in the serum creatinine. Subsequent long-term follow-up studies seem to support a permanent benefit in the fish-oil group.

Where do you get fish oil?

Fish oil is available at most health food stores, most pharmacies, and even at big box discount supermarkets. Pay attention to the "best before" or the expiry date when you buy it, as fish oil can become rancid. Also, be aware that most fish oil comes from fish that are harvested in fish farms. Some products on the market claim to be from "wild fish". Whichever you buy, you should not buy any product that does not specifically list the amount of EPA and DHA it contains.

Edema in Hands and Feet in IgA Nephropathy

Edema in Hands and Feet is a common symptoms, that is, edema in IgA Nephropathy. Why IgA nephropathy cause edema?


Protein has a specific ability to hold the water and prevents it flowing into tissues. When IgA Nephropathy attacks the kidneys, the renal filters leak much protein in the urine, which leads to proteinuria and edema.

How to deal with the swelling hands or feet caused by IgA Nephropathy?

The key is how to stop protein leakage, because protein is the main natural tool to control the water in your blood.
Chinese herbal medicine helps to repair the damaged kidneys and improve the renal filter ability. Thereby, Chinese herbal medicine alleviates protein in urine naturally. To revive the kidneys is the root way to eliminate the swelling in hands and feet.

Besides, some other useful measure may also alleviate this symptom timely, but momentarily.
● Get off your feet. Standing exacerbates swollen ankles. Sit down in a comfortable chair and relax.
● Massage. Massage your feet and hands, which increases circulation and encourage excess fluids to circulate away from the area.
● Cold compress. Apply ice mass to the swelling area. Ice is a very helpful tool to reduce the swellings. Put the ice in your feet and hands every 10 minutes.

Swelling hands and feet only is not dangerous. However, swelling caused by kidney disease will not only affect the limbs. Where is not in your sight, also will be involved. Swollen limbs or eyes may indicate the swellings in your native organs, such as swollen stomach, lung and intestine etc. This is why some patients feel hard of breath and nausea vomiting in IgA Nephropathy. The native organs swellings will cause more dangerous complications, such as heart failure, emphysema and bleeding in your enterocoelia.

Diabetes: Prepare for your Landon Olympic Travel

Landon Olympic Game 2012 makes landon become the most hottest place to travel this summer. However, if you happen to be a diabetes patient, you may prepare more for your Olympic Travel.

Packing
Pack a list of all medication. Carry a simple first-aid kit. Pack an ample supply of food and drink, providing for any delays and making sure you don’t disrupt your usual diet too much.

Stock up with diabetes drugs and insulin, taking more than you will need. If you are travelling with a partner, make sure they carry half in another case, in the event that one case is lost.

Apply for your EHIC
Apply for an EHIC (European Health Insurance) card and you can receive free cover in some European countries.

A diabetes identity card or piece of jewellery stating that you have diabetes can be a good idea.

Before you leave
Visit the family doctor, and make sure you have any recommended vaccinations.
Apart from leaving yourself open to the risk of disease, without vaccinations many travel insurance policies will be invalidated.

Don't forget your spares
Not only should you take all your normal kit, you also need to take spares. Then you need to consider how best to carry it.
If you’re going in the car, then you’ve got space, by comparison to packing – say – for a flying on a budget airline.
Hope each patients with diabetes can enjoy the Landon Travel.

Connection Between IgA Nephropathy and Low-grade Fever

Is your low-grade fever caused by IgA Nephropathy?


Low-grade fever is not a specific symptom of IgA Nephropathy only. There are several causes which may relates to low-grade fever. Some probable causes of low-grade fever are given below.

● Infection. Fevers often accompany infections and are part of your body’s natural defense against them.

● Physical activity or environmental factors. Body temperature can also be elevated by physical activity and environmental factors, such as high ambient temperature or wearing heavy clothing etc.

● Immunizations. A low-grade fever may also occur following immunizations, during teething.

● Autoimmune disease. If you have persistent fevers, it can be triggered by medical conditions, such as autoimmune disease, cancer etc. And IgA Nephropathy is a kidney disease that is caused by the underlying autoimmune disorder. Thereby, if you suffered chronic low-grade fever, it may caused by your IgA Nephropathy.


How to deal with the low-grade fever in IgA Nephropathy?

● If you have low-grade fever in IgA Nephropathy, you need to take tests firstly and your doctor will help the real cause of the low-grade fever. If the low-grade fever is not caused by medical conditions, you may need no medical innervations.

● If your low-grade fever is caused by IgA Nephropathy, immunotherapy may be necessary. IgA Nephropathy is caused by the immune disorder which releases excessive immunoglobulin A and causes overreacted inflammation. This not only causes kidney damages, but also triggers persistent fever.
Immunotherapy is used to regulate the underlying immune disorder which helps avoid the root cause of low-grade fever.

Can Diet Pills Cause Kidney Disease

Can diet pills cause kidney disease? Yes, some diet pills really causes kidney damages and even some of them develop into kidney failure finally.

Of the overweight and obese patients with kidney disease included in the survey, 50 percent reported that they had attempted to lose weight in the past year. The survey showed that, on average, obese Americans with kidney disease consume protein in amounts that are above the recommended levels prescribed by the National Kidney Foundation for chronic kidney disease patients.

The typical American diet each day includes approximately 1.2g of protein per kilogram of body weight. Patients with CKD are advised to consume 0.6g to 0.75g protein per kilogram of body weight each day and popular high-protein diets may call for up to 1.9g per kilogram of body weight.

Thereby, you are not suggested to take excessive or strong diet pills. If you happen to be a person with kidney disease, you’d better never try it. If you have to, maybe Chinese herbs are a good choice for its side-effects-free function.

Will You Pass IgA Nephropathy to Your Children

Once you are diagnosed with IgA Nephropathy and meantime a mother or father, one of your worry may be: will I pass the disease to my Children?

After many years’ research, the nephrologists don’t find the direct relation of heredity and IgA Nephropathy. But, relatively, if one of your family members has this disease, you seem to have a greater chance to develop such a disease.
The following is currently known by far:

Familial clustering. There appears to be a familial clustering of IgA nephropathy which shows strong family predisposition in about 10% of cases, with this being more common in some specific regions or in families from those regions. In the U.S., these include Kentucky and parts of the Southeast. In other parts of the world, familial clustering of IgAN seems to be more common in Southern France and Italy.

Ethnicity. In addition to the regional-based familial clustering, IgAN is known to be more common in some specific ethnic groups (although it does not necessarily run in families). IgAN is most common in people of Asian ethnicity (oriental), followed by Hispanics and then Caucasians (seems to be relatively more common among the French). It is least common in African Americans. IgAN is also more common in American Indians than it is in whites.

Not familial. Greater than 90% of IgA nephropathy is not familial (in other words, there are no other family members with the disease).

Pediatric IgA Nephropathy Symptoms

Most of the symptoms of Pediatric IgA Nephropathy, or Berger's disease seen in children are similar to those seen in adults, but they are less common or appear in different stages of the disease process.

Hematuria


Gross hematuria can be seen when the patient's urine is smoky or cloudy. The urine is darker than normal because of the red blood cells in the urine.
A strong smell might accompany the dark urine. The hematuria is not constant and occurs only during an active episode of the disease.

Abdominal Pain

Children with Berger's disease often experience bouts of excruciating abdominal pain that can mimic appendicitis. The pain can be in the middle of the abdomen or localize to the right lower quadrant.

Proteinuria

Proteinuria is the presence of large amounts of protein in the urine. The proteinuria is caused by destruction of a part of the kidney.
The kidney usually filters out protein from the urine, but IgA Nephropathy damages the kidney and prevents it from performing this function. Proteinuria sometimes can be evident when a patient notices that his urine is more foamy than normal, due to the presence of protein in the urine.

Flank Pain

Pain in the back or side regions also has been linked to IgA nephropathy.
Pruritis
Pruritis, or itchiness, commonly is seen in patients with IgA nephropathy.
Symptoms of Chronic Renal Failure
Signs of chronic renal failure include edema (swelling in the hands, feet or other parts of the body), high blood pressure, fatigue, headaches, cramps and insomnia.

Fatigue


Fatigue is one of the most common symptoms affecting patients with IgA nephropathy. The fatigue is described as overwhelming and sometimes is associated with a sore throat, headache or slight fever.

Focal Segmental Glomerulosclerosis and Gluten Free Diet

Like celiac disease, FSGS is an inflammatory disease, enflaming and scarring the glomeruli, or filtering system, of the kidneys. It was also that summer that I discovered that eliminating gluten from my diet put my disease into spontaneous, full remission, an extremely rare occurrence.

I want to share my experience with others so that others can be aware that eating gluten free does not only benefit those with celiac disease.
How did I get so lucky to go from health to serious illness back to health in a short period of time?

My health crashed & burned in the summer of 2009. I didn’t see it coming. I had seemingly sudden and unexplained weight gain caused by edema, hypertension, and high cholesterol. All signs pointed to a kidney problem, so I immediately put myself on a renal diet that happened to be nearly gluten free. A renal biopsy confirmed the diagnosis of FSGS with nephrotic syndrome.

Most people with the disease eventually progressed to End Stage Renal Disease, requiring dialysis and transplant. Stubbornly I refused to accept this was my future and refused to accept that I couldn’t figure out the cause and a solution.

It was during that time of diagnosis, doing research, checking out theories, going for follow-up tests, that my friend found stories of others with kidney disease who had gone into, and stayed in, remission merely by going on a gluten free diet.

Within five weeks, my tests showed that I was in full, spontaneous remission. It’s important to note that I had already been eating mostly gluten free for three months prior to this full commitment and was already showing vast improvement. It’s important to have a long view when giving this diet a try. My nephrologist called my improvement “remarkable” and “fabulous”. We checked again a month later, and I was even more into the healthy range. Six months later at a follow up visit, my numbers showed healthier than many healthy people without kidney disease. My nephrologist envies my blood pressure and cholesterol. Today I am still in full remission, on no medication, and still gluten free.

While a gluten free diet may help virtually all with celiac disease, it may help only some with chronic kidney disease and other medical conditions. It is not widely known, even by nephrologists, and it is not widely studied. Through word-of-mouth, I have been encouraging others with kidney disease to try this very safe diet, and I am aware of two children and two adults with kidney disease who have gone into remission as a result. Others did not see any improvement or saw unexpected improvements such as weight loss, arthritic pain gone, and insomnia cured.

5 Ways to Improve Your Kidney Function

Kidneys are the most important organs to keep you healthy. How to improve your kidney function? Ok, let’s go to find the top 5 ways.


Exercise


Another great tip that doesn’t cost you a thing is exercise. Do I really need to explain why exercise is so important? Probably not, but here is a refresher:
• Reduces the risk of diabetes, and improves blood sugar
• Lowers blood pressure
• Reduces ‘bad’ cholesterol
• Increases ‘good’ cholesterol

Drink enough water each day


Drinking about six to eight glasses of water a day can help improve kidney function in a few ways. The water helps the kidneys perform one of its main functions, which is removing waste. Water helps flush the waste out. Drinking plenty of water also helps reduce the chances of forming painful kidney stones.
Learn how to improve kidney function with cardiovascular health. Cardiovascular health is vital in maintaining and promoting the health of the kidneys. As previously stated, blood circulation is vital for kidney function. With proper cardiovascular health the kidneys are better able to correctly function. Maintaining healthy blood pressure is vital for cardiovascular health. Hypertension should be treated correctly to prevent loss of kidney function.

Chinese herbs


Many Chinese herbs are used to improve kidney functions due to its functions as follows:
Repair the damaged kidney tissues;
Accelerate blood circulation;
Supply with enough oxygen and blood to kidney lesions;
Anti-inflammation; Anticoagulation; Degradation etc.

IgA Nephropathy and Pregnance: Can I Have A Baby With IgA Kidney Disease

IgA Nephropathy is a common Glomerulonephritis which usually attacks some people in young age. What should you prepare for pregnance with IgA Nephropathy?


Factors that decides whether you can get pregnance or not


Many women with IgA Nephropathy have conceived successfully, however, your nephrologists’ recommendation or advice will depend on your individual circumstances. Factors that may be considered are degree of existing renal failure (that is, what your kidney function is, and if it's less than about 70%), the amount of proteinuria you have, whether you have high blood pressure or not, and also some of your biopsy findings (any sign of significant tubulointerstitial involvement). You might be asked to wait until your IgAN is stable, if for example, you are dealing with nephrotic syndrome, or if you are having frequent "flare-ups" involving blood in the urine.

On the other hand, pregnancy should not be automatically excluded on the basis of having IgA Nephropathy. A recent study involving 60 pregnant women with IgA Nephropathy, the conclusion was that "in pregnancy complicated with IgA Nephropathy, if the renal function before pregnancy was satisfactory, an uneventful course of pregnancy could be expected by careful control of the patient, although the incidence of EPH-gestosis was high". EPH-gestosis means essentially the same thing as pre-eclampsia. A satisfactory renal function in this case would mean a serum creatinine somewhere under 200 umol/L (equivalent to 0.20 mmol/L in some countries, or approx. 2.3 mg/dl in the U.S.), and well-controlled hypertension (on drugs that will not harm the fetus).

So, when it comes to pregnancy, no matter what you read here or anywhere else, the bottom line has to be consulting with your nephrologist, and if necessary, whatever other medical specialists are appropriate in your case.

Natural Remedy For Kidney Health: Medicated Bath Treatments

Medicated Bath Treatments one of the treatments used in Shijiazhuang Kidney Disease Hospital, China. Medicated bath is a featured treatment in this hospital. Its therapy is that steam or direct bath will take obvious functions in blood circulation or disease curing by permeation of ingredients from herb extracts. Boiling and heating will make the Traditional Chinese Medicine extracts develop the most functions. According to the Chinese medicine therapy, medicated bath will promote blood circulation and metabolism. As long as the prescription is appropriate, many health aims can be achieved.


In the west, Traditional Chinese Medicine is perhaps most closely associated with massage and acupuncture only. In fact, the major parts of TCM also include herbal medicine, medicated bath, osmotherapy etc.

Besides alleviation on kidney disease, the medicated bath in Shijiazhuang Kidney Disease Hospital also offers partial slim, smooth skin, weight loss, immunity improvement, lowering high blood pressure, appetite promotion, recovery from fatigue etc.

Many kidney disease patients feel energetic after the medicated bath. Besides the improvement of kidney condition, many patients also get “additional alleviation” and Steiger, a Lupus Nephritis patient from India called her mother excitedly after 6 times of medicated bath for her skin becomes whiter than before. And she owns it to medicated bath. “China is a magic country, like India. “ She said.

Many patients appreciate and shock by the changes caused by medicated bath and they usually recommend their families to try the magic bath at our hospital. And Warin, a lady who comes to China for her husband kidney disease treatment, tried medicated bath and lost about 5KG weight in a month. She was very excited. “this is the most easiest way to make a slim figure.”

“This is God’s medicine.” Said Yasser (click for Yasser’s story), who comes to China for his diabetes and Renal Failure. When he came to China, he walked with the support of walking stick and when he left, the stick is useless for him.
About 200 foreign patients visit our hospital each year. Besides Chinese Osmotherapy, medicated bath is also a magic power that attracts them here.

Natural Remedy of Dialysis for Kidney Failure with 10 Creatinine

Q: My father is a Kidney Failure patients and his creatinine level is 10.Here is his medical report saying:


HIS BLOOD PRESSURE IS ALSO DIFFICULT TO CONTROL.
HB 10.5
TLC 7700
CREATIN 10.9
UREA 228


 He was admitted in LRH Medical C ward for a low Hb and RBC and weakness with weight loss. His skin turned darkish. During investigations, it was found that he has kidneys problem. He was kept on dialysis, blood transfusion and repeated RFTs. In between these tests, the values of urea and creatine lowered a little but after about 48 hours pause of dialysis, the values again raised in his blood.


Is there any alternative treatment for him to stop dialysis with creatinine 10?

A: Your father’s condition is really serious. However, I think there is still hope of stopping dialysis. There is still blood flow in the kidneys and his kidneys have not shrunk much. If we give him medicine and cell treatment, the active material can still arrive at the kidneys and take effect.

I recommend Micro-Chinese medicine and cell therapy. Micro-Chinese medicine osmotherapy is a kind of external application. The Chinese herbal medicine is micronized into one thousandths of its original size. With the action of the microscope, it can arrive directly into the kidneys through skin and channels. The absorption rate and bioactivity of the medicine has been highly improved. It can expand the blood vessels, improve the blood circulation and increase the blood flow in the kidneys. In this way, the self renewal of the damaged cells will be reactivated thus recovering the kidney function.

As long as his kidney function is recovered to over 15%, he can stop dialysis.

Chinese Herbal Remedy For End Stage of Kidney Disease

The natural treatment for ESRD—Micro-Chinese Medicine Osmotherapy:

● Micro-Chinese Medicine is abstracted from the Chinese herbs, without any side-effect. This is the oldest traditional medicines in our country, like acupuncture.

● All kidney disease is caused by the renal fibrosis, which means the blood can’t flow in the vessels. Chinese Medicine can dilate blood vessels, increase the blood flow volume in the renal lesion.

● Micro-Chinese Medicine Osmotherapy is not an operation, without any pain. Chinese Medicine is superfine shattered like powder, they are putted into small bags and heated for 45 minutes, and then we put these small bags on the two sides of kidneys according to the Acupuncture Points. What’s more, this process can be achieved with the help of osmosis device, so Chinese Medicine can get into renal lesion effectively.

● The effective substance can repair the damaged renal cells, and clear the immune complex in the human body. After adopting Chinese Medicine for 3-5 days, the urine color can be changed obviously.

●Chinese Medicine has the function of anti-coagulation, anti-inflammatory,prevent thrombus,degradation.

Alternative Treatment to Kidney Transplant for ESRD with Creatinine 777

Q: My friend is a patient with ESRD and his doctor suggested kidney transplant for his creatinine level 777. Is there any alternative treatment to transplant for him?

A: At present, we think she doesn't need to do the kidney transplant, because she still has the urine output, which means her kidneys still working, so she has more chance to enhance her kidney function and delay the development of kidney disease.

What's more, her creatinine is 777, not so high, we have treated many patients whose creatinine above 1000, so we accumulated many experience on this subject, please don't worry.
After the proper treatment, your sister can have the good quality of life, her kidney function can be enhanced.

Our hospital is the largest kidney disease specialized hospital in China, it located in Shijiazhuang City, Hebei Province, China. Our characteristic treatment is Micro-Chinese Medicine Osmotherapy+Immunotherapy.
Micro-Chinese Medicine Osmotherapy is abstracted from the Chinese herbs, without any side-effect for the human body. This treatment is not surgery, not oral taking medicine, this is the external application treatment.

Immunotherapy is a kind of method to enhance the patient’s own immunity, as long as the patient’s own immunity can be enhanced, the whole body’s fighting capacity can increased greatly. For example, if some patient catch a cold, someone needs to take the medicine, but other patients don’t need to take the medicine, their own immunity can overcome the disease. Our purpose is to fight with the disease by the patient own immunity.

Kidney transplant will be not a must for ESRD, if patient’s kidney functions are improved. Hope you can prevent the last choice and choose a right treatment for your sister.

Treatment Options for Pediatric Nephrotic Syndrome

Pediatric Nephrotic Syndrome is protein excretion of more than 40 mg/m2/h. Because 24-hour urine collections are potentially unreliable and burdensome, especially in young children, many pediatric nephrologists instead rely on a single, first-morning urine sample to quantify protein excretion by the ratio of protein to creatinine.
To control the symptoms, like proteinuria in Children, the conventional treatment may include:

● Medicines, such as angiotensin-converting enzyme (ACE) inhibitors andangiotensin II receptor blockers (ARBs), to reduce the amount of protein lost in the urine, lower blood pressure, and slow the progress of the disease.
● Corticosteroids, such as prednisone or prednisolone, to reduce swelling.
● Diuretics are used to reduce fluid buildup in the body and help with reducing sodium, water and potassium.
● Salt-free albumin given through a vein. Albumin helps remove extra fluid from the tissues.

First treatment can take effects and control the symptoms in 6 to 15 weeks. However, as these conservative treatments fail to affect the underlying kidney damages, your children may need ongoing therapy which may last for months or years, or even for the rest of life. The treatment duration depends on how severe your children’s symptoms are. Another question is that various side effects, such as obesity, abnormal sexual development, short figure, vomiting etc, may come along with the long-term use of hormone therapy.


To avoid the side effects for your children’s nephrotic syndrome, Chinese herbal remedy may benefit your children a lot. Herbal remedy comes from natural plants and herbs, which causes no major side effects. When ingredients of herbs arrive at body, they can help repair the kidney damages and improve kidney function and your children will not depend on the natural therapy for his rest of life. When his impaired kidneys are repaired, the treatment can be stopped. The herbal formula varies from person to person. Some of our experts are major in herbs for Nephrotic Syndrome in Children.

Herbal Medicine Of IgA Nephropathy

Herbal medicine


An herb is a plant used for its scent, flavor or therapeutic properties. Since more than 2500 years ago, herbal remedy is used by Ancient Chinese to improve their health. Many herbs have been used for a long time for claimed health benefits. Herbal remedy spreads throughout the world and is famous for non-side effects by repairing impaired organs naturally.

Herbal remedy is applied into IgA Nephropathy patients to improve kidney functions and immunity. Herbal remedy may be utilized as tablets, capsules, powders, teas, fresh herbs, dried plants or extracts etc. And the best way is believed osmotherapy.


IgA Nephropathy


IgA Nephropathy is a common disease in which abnormal immune system generates excessive immunoglobulin A (IgA) and the abnormal deposition of IgA causes inflammation to attack the kidney filtering unites and reduce kidney function.
What to expect from herbal medicine for IgA Nephropathy

● Improve kidney function. The ingredients of herbal medicine can dredge blood vessels and supply with more blood and oxygen to kidney lesions, which benefits the impaired kidney tissues to self-cure and improve kidney function.
● Block inflammation. Herbalists around the world know of many plants with inflammation inhibiting and anti-arthritic properties. In a well known study, 163 species of plants and fungi were tested to determine their anti-inflammatory activity.
● Improve immunity. The true health can be attained only by maintaining a healthy properly functioning immune system and using home remedies can definitely help to strengthen the ability to fight IgA Nephropathy.
● Alleviate symptoms. Herbal remedy helps alleviate many symptoms naturally, such as swelling, back pain, erythema, foamy urine etc.
● No major side effect. Herbal remedy comes from the natural herbs and plants, which causes no side effects, such as obesity, infection, sexual abnormal development, swelling, vomiting etc.
● No surgery and no trauma. Herbal remedy takes effects naturally, which is not a surgery or any invasive therapy.

Herbal medicine has been used for more than 3000 years, which offers an alternative treatment for IgA Nephropathy, especially a good choice for the young children or teenagers.

Can I be a vegetarian if I have chronic kidney disease?

If you are diagnosed with chronic kidney disease (CKD) and are a vegetarian you can continue the practice. Monitor your calorie intake to make sure you are getting enough calories.

● Make sure your dialysis prescription is adjusted as needed for acceptable urea clearances.
● Include vegetarian sources of protein and calorie supplements when needed.
● Provide resources, recipes and renal education materials specific to your needs.
● Suggest a lower potassium dialysate for those on dialysis to control potassium levels.
● Increase your phosphate binders that may be needed for meals and snacks.

What's the symptoms of Renal Parenchymal Disease

If you are suspicious to Renal Parenchymal Disease, you may have the following symptoms:


blood in the urine, abnormal blood tests, high blood pressure (Renal parenchymal disease is the most common cause of secondary hypertension, and is responsible for 2-5% of all cases of hypertension), swelling in the feet and lower legs, arms, or face, and symptoms of urinary tract infection. Urinary tract infections do not usually mean kidney disease exists, but a patient should contact his physician. Loss of appetite, nausea, vomiting, fatigue, sleepiness, itching, twitching, and a metallic taste in the mouth indicate chronic kidney disease.

Diagnosis of Renal Parenchymal Disease


If you have two or more symptoms of Renal Parenchymal Disease, you may need to make tests for an accurate diagnosis. Doctors use abdominal ultrasounds to find cysts, a urine analysis and a cystic fluid exam. Elevated blood urea nitrogen concentration and serum creatinine concentrations confirm whether a patient who has had an ultrasound showing cysts has parenchymal kidney disease.

Tests for Renal Parenchymal Disease

The tests to indicate the renal parenchymal disease, include:
● A blood test, which is used to check up your GFR. GFR stands for glomerular filtering rate, which tells how well your kidneys are filtering.
● A urine test checks for albumin or blood cells in your urine. Albumin is a protein that can pass into the urine when the kidneys are damaged.
● A kidney biopsy may help find out the cause of chronic kidney disease. After a kidney transplant, a doctor may use this test if he or she suspects the organ is being rejected by your body.
● Other tests to indicate the early damages of your kidney parenchyma. These tests can replace the kidney biopsy. These tests include microglobulinβ2, Cystatin C, homocysteine, retinol binding protein, microglobulin α1, GGT, NAG, ECT etc.
Experts recommend screening people to take tests early who are in high-risk groups, such as people with diabetes or high blood pressure.

IgA Nephropathy:I Feel Stomach Acid

Kidney damages caused by IgA Nephropathy have impact on stomach function, which may lead to stomach acid. 


Each people has two kidneys locating on either side of the spin, just below the rib cage. Each kidney is about the size of your fist. Your kidneys keep some things in your body that you need and get rid of other things that you don’t. Besides urination and waste elimination, your kidneys also release some hormones to keep other organs healthy. And some of hormones are used to support your stomach and intestines functioning well. These hormones are known as “gastrointestinal hormone”.

When IgA Nephropathy develops into a serious condition, your stomach and intestines may get involved and releasing excessive stomach acid.
The side effects of hormone drugs
Compared with kidney damages, stomach acid in IgA Nephropathy patients is commonly triggered by side effects of hormone drugs, such as thunder god vine, cyclophosphamide etc.

The hormone drugs usually are used to deal with the acute inflammation and alleviate hematuria and proteinuria. Many patients usually experience IgA Nephropathy relapse, after hormone therapy.  Thereby, they need take these medicine for long time, which leads to serious side effects. And one of them is impaired stomach and intestine, which leads to stomach acid.


How to deal with stomach acid?
Usually, you are not suggested to stop the intake of hormone drugs immediately. You can have a talk with Chinese medicine therapist and get an herbal formula according to your individual condition. Many Chinese herbal medicines are restorative to digestive organs by limiting stomach acid, revitalize stomach and intestines and protect gastric mucosa etc.
However, not each herbal medicine is good for everyone suffering from stomach acid. The herbs choice and dosage depends on your individual condition.

Pediatric IgA Nephropathy Relapse

Why pediatric IgA Nephropathy easily relapse? It connects with what treatment you choose for you children, how well your children’s immunity and children fails to take care themselves.

What treatments do you choose for your children?


Many parents choose hormone medications for their children. Hormone treatment can eliminate relative symptoms of pediatric IgA Nephropathy swiftly, but it needs strict rules in dosage. Many children are troubled with relapse again and again, because their parents fail to obey their doctor’s strict rules seriously. You can’t let your children reduce or stop drugs, when you find the disappear of proteinuria or hematuria in your children. Otherwise, you will take another risk in aggravating your children’s condition.
Another reason for relapse with hormone treatment is that hormone only focuses on eliminating corresponding symptoms of Pediatric IgA Nephropathy, which actually derives from the damage of glomerular filter membrane. Ask your doctor to make some therapies in repairing the filter function of glomeruli, your children may have a better remedy from relapse.

How well about your children’s immunity?


Pediatric IgA Nephropathy is a kind of immune deficiency, which damage your children’s immunity against infection and virus. This is another reason for frequent relapse. Even a slight infection, a cold, a wound can call back the onset. You should prevent your children from these factors. Meantime, take useful measures to improve your children’s immunity, such as exercise, proper diet and supplement vitamins.

Your children fail to take care of themselves.
Many children patients are too young to take care of themselves. Sometime, they lose their attention on the change of symptoms, such as the increase or reduction of urine protein, urine blood etc. Patients should remind them to tell their discomforts at first time. Meantime, keep an eye on their daily habits which may be the triggers of the relapse.
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Is IgA Nephropathy Difficult to Cure

It can take months or years to treat IgA Nephropathy, but many suffers only find that some of their chronic symptoms never totally go away. Why dose IgA Nephropathy is difficult to cure?


● Low immunity. IgA Nephropathy is a kind of special immune deficiency. Patients have a lower immunity than normal patients. They are so weak in preventing virus invasion that any ailment can be threatener for aggravation.

● Unexplained cause. The cause of IgA Nephropathy is not known yet by far. What has been found is only that the deposits of IgA immune complex in mesangial area cause renal disorder to occur. Nobody can explain clearly how IgA immune complex deposits here. Medical doctors fail to prevent IgA Nephropathy taking place. But now what we can do is to remit the renal disorder and stop its persistent deterioration.

● Unsuccessful treating method. In most countries, people with IgA Nephropathy take their doctor’s advice to use hormone medications. However, hormone only can remit your symptoms, such as blood or protein in urine, but it fails to improve your renal function. In fact, many patients and doctors know clearly about that, but they can find another useful treating method in their own counties.

● Relapse. IgA Nephropathy is characterized with easy relapse. It is can be triggered by any inducing agents, such as cold, fatigue, infection, inflammation, bleeding, long-term hormones and so on .

Even though IgA Nephropathy is so difficult to cure, it is possible to be cured on the condition that choosing a right treatment at the early stage. It is much more efficient to risk over-treating it at the early stage than to have to treat it more extensively later.www.igasite.com

Minimal Change Disease and IgA Nephropathy

Most patients with minimal change of IgA Nephropathy only presents Hematuria and has no obvious pathological change, therefore some of them just let it go and hope it can cure itself. In fact, timely treatment is very necessary, for minimal change can aggravate patient’s condition, even progress into eventual uremia with unsuccessful control 


Minimal Change refers to that glomeruli are normal under the light microscopy and only a few parts appear to have slight broadening of mesangial area, with or without mesangial cells' proliferation. It is the level I, according to Lee’s Classification of IgA Nephropathy. The higher the level is, the severer the pathological change is.

By far, it is impossible for IgA Nephropathy disappears spontaneously without any treatment. However, if patient’s condition can be controlled at the early stage and keep it stable in a long time, patients usually can live a normal life. If not, patient’s condition will continue to aggravate and appear to have cresent, glomerulosclerosis and renal tubular fibrosis (similar with necrosis, you can refer to Grades of IgA Nephropathy) etc.

In clinic, without timely treatment, mild disease will come along with Hematuria accompanied with proteinuria, hypertension and edema etc from the simplex blood in urine. Once these obvious symptoms appear, patients always step into Level IV or Level V, which makes recovery and treatment more complex and hopeless.

According to clinical practice, if patients accept treatment to repair damaged renal tissue, stop renal persistent injury and block renal fibrosis, patients can keep their condition stable in a long time and show a good prognosis. Otherwise, patients will have to experience continuous relapse of IgA Nephropathy, which even can be triggered with mild cold or infection. Frequent recurrence
deteriorates renal fibrosis and eventually become renal failure and uremia.

What Will Happen to Me, If I Am Pregnant With IgA Nephropathy

When you are pregnant with IgA Nephropathy, your body has to work more for you and your baby. This overwork will usually aggravate renal condition, which will likely induce pregnancy complications in return.


During pregnancy, women tend to excess fluid retention, which makes mothers to have high blood pressure and the accumulation of toxic byproducts in their blood. Fetus will grow adversely when it is affected with anomaly in level of blood pressure from mother. For the reason that high blood pressure will make fetus get insufficient blood by placenta.

What’s more, if hypertension of mother can be controlled well, other risks are on the way. For example preeclampsia, it can lead to premature birth and metal retardation, as well as renal hemorrhages in mother-to-be.

Pregnancy also brings other serious health risks for both mother and fetus associated with IgA Nephropathy. The risk factors are Hypertension, Premature Labor, Miscarriage, Renal Function Declining, Urinary Tract Infections and Acute Renal Failure and so on.

In addition, IgA Nephropathy, as a kind of renal disease, can affect whole system of human body, such as immune system, mineral levels, nervous system, blood circulation and even your heart or bone. As a result, any system mentioned above may undergo risks during pregnance.

If you are suffering IgA Nephropathy while you are planning to have a baby, it is very necessary for you to have a talk with Nephrologists who will help increase the possibilities to have a healthier fetus/

The Definition of IgA Kidney Disease/Berger's Disease

Pathologic Change. 
The levels of pathologic change of IgA Nephropathy are various. At the early stage, it shows mild pathologic change, which is described as “focal”. At that time, only a few glomeruli can be found mild mesangial broadened and segmental proliferation. At the middle stage of IgA Nephropathy, the pathologic change will become more obvious. Diffuse mesangial proliferation can be found and cresent is rare to see.


Clinical manifestation. 
In clinic, IgA Nephropathy mainly presents as microscopic or gross Hematuria and/ or accompanied with proteinuria. A part of patients may appear to have nephrotic syndrome. Normally, IgA Nephropathy progresses slowly and eventually it will develop into uremia.

Common Knowledge of IgA Nephropathy.
IgA Nephropathy, or Berger’s Disease, refers in particular to a group of chronic glomerular diseases, which has similar pathological characteristics. In clinic, about 40%~45% of patients manifest as gross or microscopic Hematuria. 35%~40% of patients can appear to have microscopic Hematuria accompanied by proteinuria. The rest patients usually present nephrotic syndrome and renal failure.

Generally speaking, man has a greater possibility to have IgA Nephropathy that woman. As the pathologic levels and the damaged levels of glomeruli are various, patients should keep a sharp eye on the frequency of Hematuria, severity of proteinuria, blood pressure and renal injury. And then choose a right treatment according your own condition.

IgA Nephropathy and Urine Odor

When urine persistently smells bad or has a foul, strong or unusual odor, it indicates underlying causes of IgA Nephropathy, such as bloody urine, infection, the discharge of toxins etc.


Different smells usually indicates various potential injuries for IgA Nephropathy suffers.

Urine always presents like fishy smelling. It may be an indicator telling your blood in urine. You’d better to check urine test and see if you are undergoing Hematuria. If the answer is yes, your glomerular basilar membrane is possibly being threatened. You might as well communicate with your doctors that whether the medications you are taking for IgA Nephropathy aims at repairing glomeruli or not. Generally speaking, once your glomeruli are repaired, blood rarely appears in your urine again.

Urine odor also can follow infections with a foul smell. For instance, urine tract or cystitis can trigger the unusual scent. In this situation, you need to talk with your doctors as soon as possible and take immediate actions, for infections easily can trigger or aggravate IgA Nephropathy.

Urine odor is not always annoying signals. If it smells strong, namely, you urine has a strong ammonia quality, it may reveals that your some toxins, such as excess immune complex, are sent out through urine. Usually this happens in Chinese Medicine therapy. Many Chinese therapies have functions of degrading extracellular matrix which will removed out in urination.

In addition, odor urine also appears temporarily after eating certain food or taking certain medications. You should not worry too much about that.

IgA nephropathy: The Oxford classification

Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glomerular disease, IgA nephropathy, in which renal pathologists first undertook extensive iterative work to define pathologic variables with acceptable inter-observer reproducibility. Where groups of such features closely correlated, variables were further selected on the basis of least susceptibility to sampling error and ease of scoring in routine practice. This process identified six pathologic variables that could then be used to interrogate prognostic significance independent of the clinical data in IgA nephropathy (described in the accompanying article). 


These variables were 
(1) mesangial cellularity score; percentage of glomeruli showing 
(2) segmental sclerosis, 
(3) endocapillary hypercellularity, or 
(4) cellular/fibrocellular crescents; 
(5) percentage of interstitial fibrosis/tubular atrophy; and finally 
(6) arteriosclerosis score. Results for interobserver reproducibility of individual pathological features are likely applicable to other glomerulonephritides, but it is not known if the correlations between variables depend on the specific type of glomerular pathobiology. 


Variables identified in this study withstood rigorous pathology review and statistical testing and we recommend that they become a necessary part of pathology reports for IgA nephropathy. Our methodology, translating a strong evidence-based dataset into a working format, is a model for developing classifications of other types of renal disease.

How to Manage the mood swings of IgA Nephropathy

A good management of mood swings can slow down the course of IgA Nephropathy.

● Keep an observation on your emotion. It’s difficult for you to remember every mental change to discuss with your doctors during an appointment, so make a list of concerns and bring it with you. Keeping a journal of mood changes will be helpful, in which way, you can discuss their frequency, persistence and severity with your doctor.

● Tell your doctor. If you are experiencing anxiety, depression, fidget, please have a talk with your doctor. Your doctor can develop better plan according to your illness condition and mental state.

● Non-Medicinal Approaches to improving mood. There are daily cares which can be helpful, including staying active, eating well, taking good rest and keeping anxiety triggers under control.

● Family support. Family can be a main supportive source for patients fighting against IgA Nephropathy. Replacing the patient to ask questions and getting answers from their physicians and helping them get information from other sources (surfing information online) can help reduce patient’s uncertainty and anxiety.

A good mood shows magical power in some patients with IgA Nephropathy. It helps patients recovering from physical damages in an underlying method. For more information, see the psychological care for IgA Nephropathy Patients.

Cold, Flu and IgA Nephropath

Cold and Flu are the common cause of IgA Nephropathy Relapse.

Why does IgA Nephropathy cause the relapse?
IgA Nephropathy refers to the disorder of immunity, so patients have no strong resistance for cold virus. With virus arrive at human body, it can mix together with abnormal IgA and form into antigen-antibody immune complex. Through the carriage of blood stream, immune complex can accumulate in mesangial area and damage glomerular basilar membrane, which makes red blood cells and proteins leak out. Therefore, patients undergo Hematuria or Proteinuria again.

What should you do with such annoying cold?
Whether and you can take pills and which medicine you can choose against common cold depend on your own condition.

◆ If you are accompanied with tonsillar enlargement, please communicate with your doctor, he will decide whether tonsillectomy should be take on the basis of its severity.
◆ If you are taking hormone, you are not to advise to take any cold medicine. You need to go to hospital, for you possibly get concurrent infection.
◆ If you are out of hormones, there is no taboo in cold medicines generally. But you should under the condition of normal level in creatinine. If your creatinine level is elevated, any medicines to take should be with the permission of your doctor.

In addition, any medication which is toxic for kidney should be avoided. In fact, modern medicines have a swift improvement in symptoms of IgA Nephropathy, but they hardly work for remedying renal function. This is the root cause for a cold can trigger relapse of Hematuria or Proteinuria. Contact Mail: kidneyask@hotmail.com

Tips for Parents with IgA Nephropathy Children

As some children get IgA Nephropathy when they very young or even during infancy, you need to explain what happened to her or him, when they grow older. It is always necessary to tell kids why they should take medicines and why they must see doctors regularly. Remember to use simple words to communicate with your little kids and don’t try to hide the details.


If children think they can do some self-caring, they usually are prone to become confident and positive. You can get more suggestions about this topic or consult our online staffs.


Moderate physical activities are allowed for your kids. You can accompany your kids to walk, jogging etc. When your child wants to try another new activity or game, you’d better make sure whether it is risk for her or his condition. Competitive sports should be avoided, for instance, rugby, wrestling, kickboxing etc.

Parents always tend to protect their children with such a disease overly. However, over sheltering may lead to isolation and awkward in front of their little friend. What’s worse, it might to bring more harmful damage in their heart than physical hurt from IgA Nephropathy in a long term.

Parenting kids with IgA Nephropathy asks for more skills and psychological cares, which you can get from our free online service. Our staff will give you detailed and custom-built direction of normal life for your children.

Ways to Prevent IgA Nephropathy Relapse

This article mainly talks the ways to prevent IgA Nephropathy relapse.


What’s the root of IgA Nephropathy?


Medical experts point out that the root inducement of IgA Nephropathy is the deposits of immune complex in mesangial area, which spreads following inflammatory responses and infiltration. This is the cause of proteinuria, hematuria, edema and high blood pressure etc. Therefore, any treatment which aims at ending the relapse of IgA Nephropathy should remove these immune complex deposits

What’s the recommended treatment?

Micro-Chinese Medicine Osmotherapy, developed for about 20 years, was reflected effective in eliminating excess deposits of immune complex, after a large number of clinical practices. There are some medical components in Micro-Chinese Medicine which has ability of degrading extracellular matrix, including deposition of IgA immune complex. With the removing of the root trigger, IgA Nephropathy patients get the foundation to avoid its relapse.
With the components of Micro-Chinese Medicine arriving at renal lesion, they also can repair damage tissues with therapeutic effects, such as dilating blood vessels, anti-inflammation, anticoagulation etc. This function improves the chance to decrease its relapse.

In addition, Micro-Chinese medicine stems from natural plants and herbs, so it has no side effects on patients. Compared with conventional treatments, it won’t hurt patients’ immunity which can work as the protect against continuous relapse.

Many patients who adopt Micro-Chinese Medicine Osmotherapy keep far away from relapse of IgA Nephropathy.

What Risks Will IgA Nephropathy Bring to Me: ARF,Hypertension,NS,ESRD

Latent Risks of IgA Nephropathy

IgA Nephropathy is asymptomatic. Even though it is progressing, you may not feel too many discomforts. However, latent risks may be invading your kidneys. Patients may develop one or more of the following risks.

Hypertension

High Blood Pressure, as its alternative name, may result from the long-term deposits of IgA in mesangial area. In the contrary, high blood pressure will further aggravate the damage to your kidneys.

Nephrotic Syndrome

Without successful control, IgA Nephropathy will hurt glomeruli persistently, which may cause a group of kidney problems to occur, including high blood pressure, edema, low blood protein levels and high cholesterol, which are known as Nephrotic Syndrome.

ESRD (End Stage Renal Disease)

With IgA Nephropathy progressing, damages accumulate in glomeruli, thus kidney will fail to work well. This leads to ESRD on the way. Surely you need dialysis for temporary fix or keep waiting in the waiting list for kidney donate.

Chronic Renal Failure.

Without timely control of IgA deposits in human body, your kidney will lose its function gradually. In this condition, you maybe the candidate of dialysis or even kidney transplant for survival.

Acute Renal Failure.

With deposits of IgA accumulating, your kidneys may lose its ability to filter your blood, thus waste products and toxins may build up in your blood, which triggers Acute Renal Failure. In such cases, you may undergo hemodialysis for instant removal of body toxins.

Even though IgA Nephropathy progress slowly, latent risk may be already on it way. In order to avoid such dangers and get a better prognosis, please take actions in the remedy of IgA Nephropathy as soon as possible. 

Is Coffee Bad or Good for IgA Nephropath

Whether coffee can be expected to cheer up IgA Nephropathy suffers? You may be frustrated about the fact that coffee not only brings energy to IgA Nephropathy, but also aggravates the conditions of suffers.

Damage to immunity. Coffee contains a kind of essential oil which enhance toxins accumulation in vascular, thus damage immune system. What’s worse, IgA Nephropathy refers to immune defect. Needless to say, coffee will double to make patient’s immunity fall down.

Sleeplessness. Coffee is used to keep one’s mind awake for most drinks. However, it is not likely good for IgA Nephropathy patients. Fatigue animportant symptoms, makes many troubles for IgA Nephropathy patients. Thereby, patients should keep enough rest to remit their weakness. Besides, if patients tend to drink coffee in evening, they will be weaker from sleeplessness or even get a relapse of IgA Nephropathy by longtime insomnia.

More other damages to health. Apart from caffeine, there are other substances in coffee, such as fat, protein, carbohydrate, mineral salt etc. all of the byproducts of these substances need to be removed out by kidneys, which will make more burden for the damaged kidneys of IgA Nephropathy patients. In addition, more intake of coffee also can lead to heart disease and osteoporosis.

Renal Failure. Coffee can generate Adrenalin and Cortisol, both of which helps oneself relaxing. However, excess drink of coffee will increase the build-up of the two materials rapidly, speeding up the pace to renal failure. <

Coffee not only aggravates renal condition but also hurts other physiological systems. Therefore, it’s not a choice for IgA Nephropathy. However, IgA Nephropathy patients still have other options in drinking, such as milk. 

Will IgA Nephropathy Develop Renal Failure

Renal failure describes a medical condition in which kidneys fail to remove toxic products out from our blood. A series of systematic disorders frequently encounter in kidney disturbance, including anomaly in fluid levels, deranged acid levels, elevated level in blood pressure, bone disease or even cardiovascular disorders etc. Say to the worst, IgA Nephropathy has chance to develop into uremia after undergoing a period of renal failure.
In IgA Nephropathy, individual’s pace to renal failure presents various. Here are some statistics for your reference.
30%~40% of patients contributes to renal failure within 10 years.
1%~2% of patients develops uremia in each year.
In primary Glomerulonephritis, IgA Nephropathy accounts for 15%~30% of chronic renal failure.
Normally, IgA Nephropathy tends to Chronic Renal Failure, which is more difficult to control, compared with Acute Renal Failure. Some signals come into being, when it goes toward to renal failure, including discomforts, edema, anemia and high blood pressure etc.
Right treatment benefits to delay renal disease becoming renal failure. By far, IgA Nephropathy hardly has a good prognosis by intervention of conventional treatment, especially by hormone medications only. Such therapy makes you feel better through putting symptoms into invisibility, but your renal function still falls down gradually. As long as your renal functions are improved, IgA Nephropathy can be reversed from renal failure.
Meantime, lifestyle is always associated with the possibility of renal failure. Good life habits will help delaying the process of renal failure. Starting today, you must quit smoking and drinking; change your diet and manage a proper one for yourself; do some mild sports and activities and never make yourself too tired; prevent yourself from cold or any other infectious diseases; if you are not sure whether your lifestyle is ok or not, you might have a talk with your doctors.

Signs of FSGS Relapse

Cold and infection. They are the common signs for FSGS coming back. Many patients complain that even a mild cold or infectious ailment triggers the increase of proteins or blood in urine. As FSGS is associated with an immune disorder, any virus or bacterium easily get you involved in relapse.
Bubbles in urine. When your Proteinuria is restarting, continuous bubbles usually appear in your urine. Keep close monitor in your urine changes. If many bubbles last long time, it is extremely possible to tell your renal disease is on the back way.
Swelling. One of marked sign for recurrence is swelling in eyes. It usually appears clearly when you get up in the morning and then it is gone after a period of time. Besides, you may find edema in other parts, such as legs, ankles and hand etc.
Weight gain. Weight gain is along with generalized body swelling. If you find you become fat in a short time, please tell it to your doctor and he will provide relative suggestion.
Poor appetite. When FSGS is at the corner, some patients show bad response in appetite. They fail to take enough food and feel fatigue easily than before.
Relapse of FSGS varies in length, severity and symptoms. Above signs are general signs for your reference. If you are undergoing any of these signals or other discomforts, you need to talk with your doctors or you can communicate with our online doctors. Never just let signs go. You should remember, the sooner you find the signs, the less long-term damage will done to you.

Patient Case: IgA Nephropathy Stage

Here is a case of IgA Nephropathy Stage 3 (FSGS) who gets rid of hormones gradually and gets a better effects.


Bella, Female, 21-year-old, USA


Dropsy in eyes.
1. Bella appeared to have dropsy in eyes in June, 2007 and got examinations in local hospital. At that time, urine protein 3+, occult blood 2+, diagnosis as Chronic Nephritis. She was given anti-inflammation treatment, but there shows no response.
2. Bella transformed into another hospital in her country and tests showed urine protein 3+, occult blood 3+. Renal biopsy revealed Focal Segmental Glomerulosclerosis—stage 3. Given prednisone, GTW and cyclophosphamide for 16 months, she didn’t get better.
3. Bella was hospitalized in our hospital on 23th, April, 2010. At that time, tests showed serum albumin 33.7g/L, 24-hour uric albumen ration 1.36g, BUN and Scr are both within normal range.
4. She adopted Micro-Chinese Medicine Osmotherapy third times per day. Meantime, she took prednisone 40mg/d and cyclophosphamide 2g/d for one month.
5. Her 24-hour uric albumen ration became 0.58g when she left our hospital on 24th, May, 2010. Then she was suggested to stop cyclophosphamide and reduced the dosage of prednisone to 25mg.
6. She continued Micro-Chinese Medicine Osmotherapy at home for three months. When she got recheck in local hospital at 2th, September, 2010, she said the result as follows: Serum Albumin 33.6g/L, 24-hour uric albumen ration 0.04g. At that time, prednisone has reduced to o20mg.
Discussion
IgA Nephropathy refers to the deposits of IgA and C3 in mesangial area. The main composition of IgA in glomeruli is IgA1, which mainly comes from the effects of B cells from marrow and lymphatic system and Th2 cell, as well as dietary antigen. According to medical experts, the deposits of IgA connect with the imbalance between Th1 and Th2.
The ingredients of Micro-Chinese Medicine have ability in regulating immune system and correcting the imbalance between Th1 and Th2, which can decrease the accumulation of IgA in renal area.

FSGS Relapse Causes

FSGS is a disorder of immune system. Anyone who gets FSGS has a low immunity against external factors. Once external virus invades human body, failed immune system hardly strong enough to stop all virus, thus causing FSGS reoccurring.
Hormone medication only.
Hormone medication can eliminate symptoms, such as Proteinuria, in a short time, but hormone only fails to recover FSGS. For the reason that hormone can not affect the further cause of the disease—renal lesions. Besides, long-term hormone medication will bring side effects for patients, which may also trigger the relapse of FSGS. Meantime, the dosage of hormone medications should follow doctor’s advices, thus avoids the recurrence of FSGS induced by the regular intake of hormone.
Various inducements
Many inducements can keep FSGS recurrent, even a mild cold, fatigue, bleeding or any infections. All these triggers are around daily life, which may work as b
lasting fuse for the recurrence.
Unsuccessful treatment
FSGS results from renal injury. Proteins or blood in urine is attributed to the damage. Only the treatment focuses on the remedy of renal lesions can FSGS avoid or reduce of FSGS. Only the treatment which aims at eliminating Proteinuria or Hematuria can’t control the relapse of FSGS successfully.
Therefore, patients with FSGS should adopt right treatment and not just take hormone only, so that they can avoid or reduce its relapse. Meantime, they should improve their immunity against frequent recurrences. Besides, patients should pay attention to daily infection, cold, fatigue and so on.

Chinese herbal medicine for FSGS

Chinese herbal medicine may be a good choice for FSGS (focal segmental glomerulonepritis)

There are millions of glomeruli in your two kidneys, which serves as filters to filtrate human blood. Just like a coffee filter, it keeps useful materials and expels waste through urination. FSGS spreads scars on some glomeruli, which damages and kills some glomerular cells, thus leads to the disorder of filtration.


TCM, known as Herbal medicine, is used to repair the damaged glomerular cells in treating FSGS. Derived from natural plants or herbs, TCM has no adverse effects on patients. More important, it gives patients a remedy by repairing the filtration function of damaged glomerular cells instead of just eliminating proteinuria or hematuria outwardly. Consequently, it prevents FSGS from relapsing more effectively and more thoroughly.
Then what about the killed glomerular cells induced by FSGS? They are out of therapeutic range of TCM.

A better curative effect of combination of TCM depends on your timely adoption. How much your glomerular function can achieve greatly lies on how well your present glomerular state is.

How Get Rid of Side Effects for your Kids with FSGS

How to get rid of side effects for your kids with FSGS? Natural Treatment and life style changes may a good choices.

Natural Treatment


Traditional Chinese Medicine prevails all over the word as famous its non-toxic property. Medical experts of Chinese medicine collect a series of herbs or plants containing material which helps remedying FSGS with its special curative effects, such as degrading immune complex, resisting inflammation and dilating blood vessels etc. After herbs and plants are boiled together, the medicine soup is used as oral administration for patients to recover their renal damage induced by FSGS. The medicine soup tastes a little bitter. If your kids can’t bear such a taste, external application is suggested for you to consider. (our online service provide external application information without charge)

Lifestyle changes


Arrange a better diet for your kids. Provide less salty food for her or him, which can help reduce water retention, remedying swelling in legs, eyes or feet.
Take some moderate exercise, such as walking and jogging, which improves your kids’ immune function.
Cheer up your kids. Good emotions assist to get rid of fret from your kid. You are suggested to build your kids confidence of recovery. Positive thinking usually gathers good results.

What Causes FSGS (Focal Segmental Glomerulonephritis)

Primary causes of FSGS (Focal Segmental Glomerulonephritis)
Primary causes of FSGS means that doctors have not found its underlying causes. Usually, it presents as Nephrotic Syndrome. However, there are several currently genetic reasons which are associated with FSGS.
● ACTN4. It encodes alpha-actinin 4. This protein crosslinks bundles of actin filaments and is present in the podocyte. Mutations in this protein associated with FSGS result in increased affinity for actin binding, formation of intracellular aggregates, and decreased protein half-life.
● TRPC6. It encodes a member of the canonical family of TRP channels. This family of ion channels conducts cations in a largely non-selective manner.
● CD2AP or CMS. The protein expressed by this gene is expressed in podocytes where it interacts with fyn and synaptopodin.
● APOL1. According to Nephrologists, these variants arose as a defensive mechanism againstTrypanosoma brucei rhodesiense or some other sub-Saharan parasite despite conferring high susceptibility to FSGS when inherited from both parents.
● INF2. It encodes a member of the formin family of actin-regulating proteins. The observation that alterations in this podocyte-expressed formin cause FSGS emphasizes the importance of fine regulation of actin polymerization in podocyte function.
● NPHS2. Mutations in the NPHS2 gene, which codes for the protein called podocin, can cause focal segmental glomerulosclerosis.
Secondary cause of FSGS (Focal Segmental Glomerulonephritis)
Secondary cause of FSGS means that it is associated with the other disorders.
● Infections, including HIV, Hepatitis B and Parvovirus.
● Diseases, such as massive obesity, sickle cell nephropathy and congenital cyanotic heart disease.
● The damage to glomeruli. There are thousands of tiny filters in kidneys, called glomeruli, which overworks to push their limits by other diseases.
No matter primary or secondary FSGS causes, it is sure that FSGS results from the damage of glomerular basement membrane. What we can do is to repair the impaired glomeruli, thus avoids or delay the progress of FSGS (Focal Segmental Glomerulonephrits)

Immunotherapy for FSGS

No matter which stage of FSGS you are stepping in, it is sure that damaged and failed renal cells leads to the following disorders. As long as the failed and damaged cells are repaired or replaced by new ones, you will have the chance to reverse your poor condition, such as Proteinuria, Hematuria and backache etc. Cord Blood Immunotherapy always are regarded the saver. After transplanted into human body, immunotherapy can move to failed cells and perform similar renal function. In this way, you will get a healthier kidney. If you can also repair your damaged cells, you are surely welcomed to possess normal kidneys. The key is to find an effective immunotherapy.
Compared with other immunotherapy, cord blood immunotherapy shows more effective in treating FSGS. After childbirth, umbilical cord usually is throw away together with placenta. The collection of cord blood immunotherapy begins after the mother gives birth to a child. There is not any effects on mother or fetus. In other words, collection of cord blood immunotherapy turns “waste” into wealth.
Compared with other immunotherapy, cord blood immunotherapy have a high concentration and high quality, whose concentration rate is 15~20 times higher than that of bone marrow immunotherapy. Meantime, cord blood immunotherapy has a higher generative ability than others. As placenta has a good filter ability, so cord blood immunotherapy has a higher purity. For this reason, cord blood immunotherapy has a lower rate to get infection.
As an advanced medical technique, cord blood immunotherapy can absolutely provide you benefit. It may bring you a better effect and healthier life, which you have never expected. If you are tired of relapse of FSGS, unsatisfactory curative
effects from other therapies, you can mail to kidneyask@hotmail.com
Can you stop FSGS early?

Diet For Focal Segmental Glomerulonephritis (FSGS)

◆ FSGS is the Stage 3 of IgA Nephropathy. At the first two stages, high blood pressure rarely appears (lower than 5%~10%). With the disease developing, the morbidity of hypertension tends to become higher. When it progresses into FSGS, hypertension will become one common symptom of patients. At that time, patients might take some food which helps preventing the elevation of blood pressure. Such as, fresh green vegetables, sea-tangle, agaric, oat, black rice, black fungus, nori etc. Meantime, patients can drink green tea or yoghourt.
◆ Control the intake of energy; patients are advocated to complex carbohydrates, such as amylum starch, corn etc, so as to avoid the increase of blood fat.
◆ If you are suffering from severe edema or hypoproteinemia, you should take enough rest. Take high quality protein with the stand of 1g/KG/Day. You need enough heat (30~35 kilocalorie), but you are not advised to take high protein diet. (high quality protein≠high protein).
In edema, patients should take low-salt (3~6g/d) diet instead of salt-free diet. You can take less high saturated acid food (animal fat) and take more low saturated food (plant oil) or high soluble fiber (vegetables, oat and rice bran).
◆ As FSGS patients usually take long time of hormone medicines, they also can supplement some calcium medicine, such as calcium tablet.
The above information is for your reference. However, diet plans for FSGS (Focal Segmental Glomerulonephritis) vary from condition to condition.